The Most Annoying Sound trope as used in popular culture. Most Video Games use audio cues as well as visual cues to let the player know what is going on . Top 10 Most Annoying Sounds. The use of vuvuzelas — a long plastic horn popular with South African soccer fans — at the World Cup has sparked debate. 16 Oct A new study examines the neurological basis for unpleasant noises—and finds exactly which sounds are the most irritating.